ABSTRACT: This study evaluated chromium and quantitative and qualitative feed restriction as alternative nutritional strategies to ractopamine in finishing barrows. Fifty barrows, genetically similar, with an initial body weight of 99.0 ± 4.3 kg and a final body weight of 117.2 ± 5.8 kg were used. The animals were distributed in a randomized complete block design with five nutritional treatments (Control; Rac = 10ppm ractopamine; Chromium = 0,8mg chromium yeast; Quality = qualitative restriction, 7.5% less net energy in the diet; Quanti = 15% quantitative reduction in feed supply), with five replicates and two animals per replicate. Chromium supplementation and quantitative feed restriction reduced feed, lysine, net energy, and crude protein intakes (P < 0.05). Chromium, ractopamine, and quantitative restriction improved feed conversion (P < 0.05). Supplementation with chromium and ractopamine and feed restriction did not influence the carcass characteristics of the pigs (P < 0.05). Quantitative feed restriction and supplementation of 0.8mg of chromium yeast are presented as potential alternatives to ractopamine in the diet of finishing pigs.

RESUMO: O estudo foi conduzido com o objetivo de avaliar o cromo e restrições alimentares quantitativa e qualitativa como estratégias nutricionais alternativas a ractopamina para suínos machos castrados em terminação. Foram utilizados 50 suínos machos castrados, geneticamente similares, com peso inicial de 99,0 ± 4,3 kg e final de 117,2 ± 5,8 kg. Os animais foram distribuídos em delineamento experimental de blocos ao acaso em cinco tratamentos nutricionais (Controle; Rac = 10ppm de ractopamina; Cromo = 0,8mg de cromo levedura; Qualit = restrição qualitativa com menos 7,5% de energia líquida na dieta e Quanti = redução quantitativa de 15% no fornecimento de ração), com cinco repetições e dois animais por repetição. A suplementação de cromo e a restrição alimentar quantitativa reduziram (P < 0,05) os consumos de ração, lisina digestível, energia líquida e proteína bruta. O cromo, a ractopamina e a restrição quantitativa melhoraram (P < 0,05) a conversão alimentar. A suplementação de cromo, ractopamina e as restrições alimentares não influenciam (P < 0,05) as características de carcaça dos suínos. A restrição alimentar quantitativa e a suplementação de 0,8 mg de cromo levedura se apresentam como potenciais alternativas para a substituição da ractopamina nas dietas.

Chagas disease, caused by the parasite Trypanosoma cruzi, occurs most commonly in Latin America. As the treatment is highly toxic and ineffective in the chronic phase of the disease, alternative treatments are needed. Through quantitative structure-activity relationship modeling (QSAR) analysis using ligand-based and structure-based virtual screening methods, we predicted the trypanocidal potential of 47 neolignans against three targets, the enzymes cruzain, trypanothione reductase, and sterol 14-alpha demethylase. A combined analysis allowed for the selection of potent inhibitors against Trypanosoma cruzi. Of these compounds, two were isolated and shown to inhibit the growth of epimastigotes at concentrations of 9.64 and 8.72 µM, and trypomastigote forms at 4.88 and 2.73 µM. Therefore, the compounds (2R, 3R)-2,3-dihydro-2 (4 methoxyphenyl)-3-methyl-5-(E)-propenylbenzofuran (46) and ottomentosa (47) may be a good option of growth inhibitors for the parasite stages and warrant additional study.

ABSTRACT Objective: Autism spectrum disorder (ASD) affects cognitive development and social interaction on different levels. Genetic and environmental factors are associated with secondary ASD. Genetic inheritance is mainly polygenic, and 10% are copy number variations (CNVs). Array comparative genomic hybridization (array-CGH) is used to identify CNVs. This report aimed to discuss autism spectrum disorder and its diagnosis by array comparative genomic hybridization, highlighting the association with the pathogenic duplication of 17q12q21.2. Case description: A male baby was born at 37 weeks’ gestation by cesarean section. The child showed strabismus, cryptorchidism, hypertelorism, frontal bossing, and developmental delay, walking at 25 months and talking at 4 years. At the age of 2 years, array-CGH of peripheral blood revealed a 5.6-Mb 17q12q21.2 duplication or arr 17q12q21.2 (34,815,527-40,213.109)x3 encompassing 190 genes, including HNF-1B and LHX1. The child was clinically diagnosed with ASD. Comments: Changes in the 17q12 segment, such as the duplication found, have been associated with the development of several problems in previous studies, mainly kidney diseases and behavioral disorders. Located at this chromosome region, HNF1's homeobox B codes a member of the superfamily containing homeodomain of transcription factors. Another gene associated with abnormalities in neurological development regarding 17q12 deletions is LHX1, as shown in this case study. LHX1 plays a role in the migration and differentiation of GABA neurons, modulating the survival of pre-optical interneurons, thus affecting cellular migration and distribution in the cortex. Changes in this control result in flaws in interneuron development, contributing to the pathophysiology of psychiatric diseases.

RESUMO Objetivo: O transtorno do espectro autista (TEA) afeta o desenvolvimento cognitivo e a interação social em diferentes níveis. Fatores genéticos e ambientais estão associados a TEA secundário. A herança genética é principalmente poligênica e, em 10%, são variações do número de cópias (CNV). A hibridização genômica comparativa de array (array-CGH) é usada para identificar CNV. Este relato objetivou discutir o TEA e seu diagnóstico por array-CGH, destacando a associação com a duplicação patogênica do 17q12q21.2. Descrição do caso: Um bebê do sexo masculino nasceu com 37 semanas de gestação por cesariana. A criança apresentou atraso no desenvolvimento, andando aos dois anos e um mês e falando aos quatro, exibindo estrabismo, criptorquidia, hipertelorismo e saliência frontal. Aos dois anos, o array-CGH de sangue periférico revelou duplicação de 5,6 Mb 17q12q21.2 ou arr 17q12q21.2 (34.815.527-40.213.109) x3 abrangendo 190 genes, incluindo HNF1B e LHX1. A criança foi clinicamente diagnosticada com TEA. Comentários: Alterações no segmento 17q12, como a duplicação encontrada, têm sido associadas ao desenvolvimento de patologias renais e distúrbios comportamentais. Localizado nessa região cromossômica, o HNF1B codifica um membro da superfamília que contém o domínio dos fatores de transcrição. Outro gene foi associado a anormalidades neurológicas, em relação às deleções 17q12, o LHX1, como mostrado neste caso. O LHX1 desempenha um papel na migração e diferenciação dos neurônios GABA, modulando a sobrevivência dos interneurônios pré-ópticos e afetando, assim, a migração e distribuição celular no córtex. Mudanças nesse controle resultam em falhas no desenvolvimento dos interneurônios, contribuindo para a fisiopatologia das doenças psiquiátricas.

Abstract Schizophrenia is an illness that affects 26 million people worldwide. However, conventional antipsychotics present side effects and toxicity, highlighting the need for new antipsychotics. We aimed to evaluate the cytotoxicity of haloperidol (HAL), clozapine (CLO), and a new molecule with antipsychotic potential, PT-31, in NIH-3T3 cells. The neutral red uptake assay and the MTT assay were performed to evaluate cell viability and mitochondrial activity, morphological changes were assessed, and intracellular reactive oxygen species (ROS) detection was performed. HAL and CLO (0.1 μM) showed a decrease in cell viability in the neutral red uptake assay and in the MTT assay. In addition, cell detachment, content decrease, rounding and cell death were also observed at 0.1 μM for both antipsychotics. An increase in ROS was observed for HAL (0.001, 0.01 and 1 μM) and CLO (0.01 and 1 μM). PT-31 did not alter cell viability in any of the assays, although it increased ROS at 0.01 and 1 μM. HAL and CLO present cytotoxicity at 0.1 μM, possibly through apoptosis and necrosis. In contrast, PT-31 does not present cytotoxicity to NIH-3T3 cells. Further studies must be performed for a better understanding of these mechanisms and the potential risk of conventional antipsychotics.

Abstract Objective Brazil Health Ministry’s guidelines for tobacco control include the Smoking Cessation Program, developed by the Instituto Nacional de Câncer of Brazil. This review aims to describe the studies in which this Program has been applied, reviewing its procedures, effects, potential and limitations. Method Articles from PubMed, PsycINFO, Virtual Health Library and Scientific Electronic Library Online, published between 2002 and 2019, were evaluated, using the descriptors “Smoking Cessation Program” and “smoking cessation” in Portuguese, Spanish and English. A total of 1670 articles were pre-selected, of which 15 resulted eligible for final assessment. Results The results showed adherence rates from 33% to 100%, success rates from 15% to 85% after the intervention and 21% to 51% six months after treatment completion. This variability may be related to the lack of standardization and poor fidelity in the application of the Program, which intends to treat physical, psychological and behavioral dependence. Conclusion Investment in technical training and record monitoring is suggested.

Resumo Objetivo Entre as diretrizes do Ministério da Saúde para controle do tabagismo está o Programa de Cessação do Tabagismo, desenvolvido pelo Instituto Nacional do Câncer. Esta revisão objetiva descrever as pesquisas que aplicaram o Programa de Cessação do Tabagismo, analisando seus procedimentos, efeitos, potencialidades e limitadores. Método Foram avaliados artigos das bases PubMed, PsycINFO, Biblioteca Virtual da Saúde e Biblioteca Eletrônica Científica Online publicados entre 2002 e 2019 e encontrados através de busca que usou os descritores: “Programa Nacional de Controle do Tabagismo” e “cessação do tabagismo” em português, espanhol e inglês. Foram pré-selecionados 1670 artigos, dos quais 15 foram elegíveis para análise final. Resultados Os resultados mostraram taxas de adesão ao tratamento de 33% a 100%, taxas de sucesso de 15% a 85% após a intervenção e de 21% a 51% seis meses após o final do tratamento. Essa variabilidade pode estar relacionada à falta de padronização e baixa fidelidade na aplicação do Programa, que propõe tratar as dependências física, psicológica e comportamental. Conclusão Recomenda-se investimento em capacitação técnica e monitoramento dos registros.

Abstract Resolution 658/2022 of the Brazilian Regulatory Agency requires the determination of the permitted daily exposure (PDE) of pharmaceutical agents. Ginkgo biloba L. is used therapeutically to treat memory deficits and other brain diseases. However, published results indicate that more studies are needed to confirm the safety of Ginkgo biloba. This study aimed to evaluate the dry extract of Ginkgo biloba L. leaves PDE as an ingredient in an oral pharmaceutical product in preclinical studies using mice. Acute oral toxicity and repeated dose experiments were performed based on OECD guidelines, as well as genotoxicity tests. The results indicate that Ginkgo biloba L. has low acute toxicity, no liver toxicity, and does not alter blood glucose levels. No changes in weight gain were observed, but food intake decreased in males during the first week of treatment at the highest dose. Hematological parameters were not altered in males, whereas females presented lower leukocyte and lymphocyte counts and higher neutrophil counts at the highest dose. The lipid profile was not altered in males, whereas total cholesterol was increased in females. The estimated PDE was 0.1 mg/day and, when related to the maximum residual concentration, indicates that the cleaning process used is safe and does not require reassessment.

Phytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-abietane diterpene named 11β,12β-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12α-olide (1), and of nine known ent-abietane diterpenes jolkinolide A (2), jolkinolide E (3), euphorin H (4), euphopilolide (5) jolkinolide F (6), ent-12-hydroxy-12[R]-abieta-8(14),13(15)-dien-16,12-olide (7), ent-11α-hydroxyabieta-8(14),13(15)-dien-16,12α-olide (8), 17-hydroxyjolkinolide B (9) and caudicifolin (10). The structures of all compounds were established using spectroscopic techniques such as 1D and 2D NMR, and the structure of the compound 1 was established also with MS, IR and ECD. All compounds were submitted to an in silico study through of a predictive model and then submitted to in vitro tests against Mycobacterium tuberculosis and M. smegmatis for evaluation of their antimycobacterial activity. Compounds 5 and 9 showed mycobacterial growth inhibition with MIC values of 62.5 μM against M. tuberculosis and M. smegmatis, respectively.

Resumo A partir de uma pesquisa de mestrado realizada com a Comissão de Aferição da Autodeclaração Étnico-Racial da Universidade Federal da Bahia (UFBA), este texto busca refletir sobre a fraude branca no sistema de cotas raciais que, na experiência de heteroidentificação racial, faz um corpo mestiço-negro. Esse fazer corporal, por meio da manipulação estética, é compreendido dentro do dispositivo da mestiçagem, e definido como um conjunto de técnicas discursivo-corporais, materialmente complementar ao mito da democracia racial. Dois outros fenômenos cruzam essa questão: o crescimento populacional negro no Brasil e a ampliação das políticas afirmativas destinadas a esse grupo. Mais pessoas estão denominando-se negras e, consequentemente, reivindicando acesso às cotas. Dessa forma, o problema do branco fraudador está sendo pensando, neste texto, em paralelo àqueles comumente apontados como “negros de pele clara” ou “pardos”: pessoas que se tornaram negras são as mesmas que fazem um corpo mestiço-negro para acessar as cotas?

Abstract Based on a master's research featuring the Ethnic-racial Self-declaration Assessment Committee of Bahia Federal University (UFBA), this paper aims to ponder over the white fraud in the racial quota system, which fabricates a mixed-black body in the context of racial heteroidentification. Such corporal fabrication, carried out through aesthetic manipulation, is comprehended within the miscegenation dispositive and defined as a set of corporal-discursive techniques materially complementary to racial democracy discourse. Two other phenomena intersect this question: the increasing number of black people in Brazil and the widening of affirmative actions targeting such group. As more people identify themselves as black, the access demand to quota system gets bigger. Thus, the white fraud issue is being addressed, in this paper, in parallel of those usually referred to as “light-skinned black” or “pardo (mixed)”: are the people who became black the same ones who fabricate a mixed-black body to have access to quota?

RESUMO: Realizou-se este estudo com o objetivo de avaliar níveis de energia líquida (EL), mantendo a relação caloria: nutriente, no desempenho e características de carcaça de suínos dos 30 aos 70 kg. Foram utilizados 60 suínos machos castrados, com pesos iniciais de 31,94 ± 3,54 kg e finais de 71,98 ± 5,99 kg. Os animais foram distribuídos em delineamento experimental de blocos casualizados, em cinco níveis de EL (2,40; 2,45; 2,50; 2,55; 2,60 Mcal de EL kg-1 de dieta), com seis repetições e dois animais por unidade experimental. O período experimental foi dividido em fase I: 30 aos 50 kg e fase II: 50 aos 70 kg. As variáveis analisadas foram os consumos de ração diária (CRD), energia líquida (CEL) e lisina digestível (CLdig), ganho de peso diário (GPD), conversão alimentar (CA), peso final (PF), conversão de lisina digestível: ganho (CLdig:G), custo: ganho (C:G), área de olho de lombo (AOL), profundidade de músculo (PM), espessura de toucinho da primeira camada (ET1), espessura de toucinho da segunda camada (ET2), espessura de toucinho total (ETt), percentual de carne magra (CM) e o índice de bonificação de carcaça (IB). Dos 30 aos 50 kg, verificou-se aumento linear (P < 0,05) do PF, GPD e dos CEL e CLdig com o aumento dos níveis de EL na dieta. Dos 50 aos 70 kg, o aumento dos níveis de EL na dieta promoveu melhora linear (P < 0,05) do PF, GPD, CEL, CLdig e da CA dos suínos. No período total, verificou-se aumento linear (P < 0,05) do GPD, CEL, CLdig e melhora linear (P < 0,05) da CA de acordo com o aumento do nível de EL na dieta. As demais variáveis de desempenho não foram afetadas (P > 0,05) pelos níveis de EL. Verificou-se aumento (P < 0,05) da ET2 de acordo com o aumento do nível de EL, porém sem alterar (P > 0,05) as demais características de carcaça. Recomenda-se o nível 2,60 Mcal de EL kg-1 de dieta para suínos machos castrados dos 30 aos 70 kg.

ABSTRACT: This study evaluated the effect of dietary net energy (NE) levels on growth performance and carcass characteristics of barrows from 30 to 70 kg of body weight (BW). Sixty barrows with initial body weight (IBW) of 31.94 ± 3.54 kg and final body weight (FBW) of 71.98 ± 5.99 kg were allotted to one of five dietary NE levels (2.40, 2.45, 2.50, 2.55, and 2.60 Mcal kg-1), using a completely randomized block design with six replicates and two barrows per replicate. The experimental period was divided into phase I: 30 to 50 kg and phase II: 50 to 70 kg. The variables analyzed were average daily feed intake (ADFI), net energy intake (NEI), digestible lysine intake (LysI), average daily gain (ADG), feed conversion (FC), FBW, digestible lysine conversion:gain (LysI:G), Cost:Gain (C:G), loin eye area (LEA), muscle depth (MD), first backfat layer (BF1), second backfat layer (BF2), total backfat (BFt), lean meat percentage, and carcass bonus index (BI). In phase I, there was a linear increase (P < 0.05) in FBW, ADG, NEI, and LysI with increasing NE levels in the diet. In phase II, increasing dietary NE levels also increased (P < 0.05) FBW, ADG, NEI, LysI, and FC linearly. Overall, there was a linear increase (P < 0.05) in ADG, NEI, LysI, and FC with increasing NE levels in the diet. The other performance variables were not affected (P > 0.05) by the NE levels. There was an increase (P < 0.05) in BF2 with increasing NE levels, but the other carcass characteristics were not altered (P > 0.05). We recommended 2.60 Mcal of NE kg-1 in the diet for growing barrows from 30 to 70 kg.

RESUMO: Realizou-se este estudo com o objetivo de avaliar as suplementações de cromo e a restrição energética em substituição a ractopamina para leitoas em terminação tardia. Foram utilizadas 60 leitoas, com pesos inicial de 98,87±0,25 kg e final de 122,69 ± 10,97 kg, distribuídas em delineamento de blocos ao acaso com cinco dietas: controle; cromo levedura (0,8 ppm); picolinato de cromo (0,48 ppm); ractopamina (20 ppm) e restrição energética (redução de 150 kcal de EMkg-1 de ração), com seis repetições e dois animais por unidade experimental. A dieta contendo ractopamina proporcionou melhor (P<0,05) conversão alimentar e maior peso de carcaça quente das leitoas. A dieta contendo ractopamina apresentou menor (P<0,05) custo de ração por quilograma de ganho e maior índice de eficiência econômica em relação as dietas contendo cromo e restrição energética que, por sua vez, foram superiores em comparação a dieta controle. Dietas suplementadas com cromo e ractopamina apresentaram maior (P<0,05) percentual e quantidade de carne magra e maior índice de bonificação de carcaça em relação a dieta controle e restrição energética. Concluiu-se que a redução energética não prejudica as respostas das leitoas em relação a dieta controle. A suplementação de ractopamina possibilita melhor conversão alimentar, menor custo de ração por quilograma de ganho e maior índice de eficiência econômica. As suplementações de cromo e ractopamina expressam aumento do percentual e quantidade de carne magra e do índice de bonificação das carcaças. O picolinato de cromo e o cromo levedura são potenciais substitutos a ractopamina para otimizar as características de carcaça das leitoas.

ABSTRACT: This study evaluated chromium supplements and energy restriction as substitutes for ractopamine in the diets of late finishing gilts. Sixty gilts were used, with initial weights of 98.87 ± 0.25 kg and final weights of 122.69 ± 10.97 kg, distributed in a randomized block design with five diets: control; yeast chromium (0.8 ppm); chromium picolinate (0.48 ppm); ractopamine (20 ppm) and energy restriction (reduction of 150 kcal of EM kg-1 of feed), with six replicates and two animals per experimental unit. Feeding diet containing ractopamine enabled better (P<0.05) feed conversion and greater weights of the hot carcass of the gilts. The diet containing ractopamine exhibited a lower (P<0.05) cost of feed per kilogram of gain and higher economic efficiency, when compared to diets containing chromium and energy restriction; these exhibited better outcomes, compared to the control diet. Diets supplemented with chromium and ractopamine resulted in a higher (P<0.05) percentage and quantity of lean meat and a higher rate of carcass bonus, when compared to the control diet and energy restriction. The energy reduction did not harm the gilts’ responses, compared to the control diet. Ractopamine supplementation allowed for a better feed conversion, lower feed cost per kilogram of gain, and a higher economic efficiency index. Supplements of chromium and ractopamine increased the percentage and quantity of lean meat and the bonus index of the carcasses. Therefore, chromium picolinate and chromium yeast are potential substitutes for ractopamine for optimizing the gilts carcass characteristics.

THE USE OF FREE SOFTWARES IN PRACTICAL CLASS ABOUT THE MOLECULAR FILTERS OF ORAL BIOAVAILABILITY OF DRUGS. The study of the physical chemical properties to predict the oral bioavailability of drugs is a widely tool used by researches on the Pharmaceutical and Medicinal Chemistry field. Even though it is a deeply studied subject, it is a complex task to teach to pharmacy students. Lipinski stablished that molecular weight, lipophilicity, hydrogen bond donors and acceptors are of great importance for oral bioavailability. In addition, Veber and Lovering added other properties, such as number of rotatable bonds, fraction of sp3 hybridized carbon and polar surface area that amplified the Lipinski Rule of 5. In this sense, the access to chemical databases and the comprehension of this information is an important task to undergraduate and graduate students. Thus, this work aims a new teaching methodology that values the critical interpretation of data and that favors the students comprehension beyond stablished rules.

RESUMO Por um período os estudos sobre documento na Ciência da Informação foram deixados de lado em favor dos estudos sobre a informação. Nas últimas décadas os pensamentos de Paul Otlet e Suzanne Briet sobre o conceito de documento foram resgatados e inseridos na Ciência da Informação. Este estudo analisa a reaproximação da Documentação e da Ciência da Informação, na perspectiva do movimento Neodocumentalista. Foi realizada uma pesquisa bibliográfica, apresentando um breve histórico da Documentação e suas relações com a Ciência da Informação. Após revisão de literatura, expõe alguns fatos sobre a formação do novo movimento, nomeado como movimento neodocumentalista ou neo documentação. Conclui ser oportuna a discussão sobre documento e informação para possibilitar uma melhor compreensão sobre ambos os conceitos.

ABSTRACT For a while, the studies about document in Information Science was left aside on behalf of the studies about information. In last decades, Paul Otlet’s and Suzanne Briet’s thoughts have been rescued and inserted in Information Science. This paper analyses the rapprochement between Documentation and Information Science in the perspective of Neodocumentalist moviment. A bibliographic research was realized, by presenting a brief history of Documentation and its relation with Information Science. It was realized a review of literature and some facts were exposed about the formation of the new movement, named as neodocumentalist movement or neodocumentation. It concludes the debate about document and information is important for a better understanding about both concepts.

Abstract The Environmental enrichment technique, although scientifically recognized for raising the level of animal welfare, has led to the questioning of its influence on the results of experimental research. Thus, the goal is to promote reflection about the need for standardization of these procedures. For that, documents and experimental analysis were done, in order to quantify and characterize the types of environmental enrichment used and to evaluate the effect of that in the social behavior of Rattus norvegicus. Data from the document review confirmed the hypothesis that the researchers have used a variety of methods, not demonstrating a concern for standardization and prior assessment of its effects on the search results. Demand was corroborated in the experimental study in which, although there was available a simple object acting as refuge promotes behavioral improvements, the presence of the co-specific, as well as characteristics of the micro and macro environment can compromise the homogeneity of the sample. The data from this study endorse the need for validation procedures of environmental enrichment for specific proposals, to investigative data comparison, are possible and contribute to the refinement of the search to reduce the number of animals targeted for this purpose.

ABSTRACT This study was conducted to evaluate different nutritional plans of net energy (NE) with a constant calorie:nutrient ratio on the performance of piglets from 7 to 30 kg. Sixty barrows with an initial weight of 7.11±0.89 kg were distributed among five nutritional plans: two NE-decreasing plans (A and B, starting from NE concentrations of 2.47 and 2.52 Mcal kg−1, respectively, and ending both at 2.37 Mcal kg−1) and three NE-constant plans (C, 2.37 Mcal kg−1; D, 2.42 Mcal kg−1; and E, 2.47 Mcal kg−1). The nutritional plans were composed of two decreasing plans: A, 2.47-2.42-2.37-2.37-2.37 Mcal of NE kg−1 of feed; B, 2.52-2.47-2.42-2.37-2.37 Mcal of NE kg−1 of feed; and three constant plans: C, 2.37 Mcal of NE kg−1 of feed; D, 2.42 Mcal of NE kg−1 of feed; E, 2.47 Mcal of NE kg−1 of feed, from 7 to 10, 10 to 15, 15 to 20, 20 to 25, and 25 to 30 kg, respectively, with six replicates per treatment and two animals per experimental unit. Animal performance was evaluated through the following measurements: average daily feed intake (ADFI), NE intake, standardized ileal digestible lysine intake (SID Lys intake), average daily gain (ADG), feed:gain ratio (F:G), final weight (FW), feed cost per kg of weight gain (CWG), economic efficiency index (EEI), and fecal score. Piglets’ final weight was 32.95±3.30 kg. Considering the total experimental period, there was no effect of the nutritional plan on ADG, F:G, CWG, and EEI. The final weight of piglets under plan D was higher than that recorded for those allocated to plan C, not differing from the other nutritional plans. Piglets fed under nutritional plans A and D presented higher ADFI compared with those subjected to other plans. Net energy and SID Lys intakes were significantly higher in piglets subjected to plans A, D, and E compared with those under plans B and C. Net energy nutritional plans did not influence the fecal score and the occurrence of diarrhea of the piglets. Based on our analysis, a nutritional plan containing a constant NE level of 2.42 Mcal kg−1 of feed may be recommended for piglets from 7 to 30 kg.

Abstract This study was conducted to evaluate the period of chromium yeast supplementation on lipid profile of backfat and Longissimus lumborum muscle of barrows. It was evaluated carcass samples from forty barrows, genetically similar. Pigs diets were supplemented with 0.4 mg kg-1 of chromium yeast in four periods (0, 38, 62 and 94 days before slaughter). The experimental design was completely randomized with four treatments, ten replicates, and each experimental unit consisting of one animal. Lipid profiles of backfat and Longissimus lumborum muscle were analyzed by gas chromatography. The increase in the period of chromium yeast use had a quadratic effect (P<0.05) for stearic and oleic fatty acids, and total saturated, monounsaturated and unsaturated fatty acids in backfat. DH-γ-linolenic and arachidonic fatty acids reduced when the period of chromium yeast use increased. In the meat, there was a quadratic effect (P<0.05) only in the γ-linoleic fatty acid. The use of chromium yeast for different periods influences the lipid profile of the backfat and the Longissimus lumborum muscle, with less effect in the meat.